# PubChem `dev.mcpharbor.gateway/pubchem`, version 1.0.0 PubChem chemistry: compound properties, molecule structures, SMILES, safety, bioassays - MCP endpoint: `https://gateway.mcpharbor.dev/mcp/pubchem` for this server alone, or `https://gateway.mcpharbor.dev/mcp` for every server - Authentication: `Authorization: Bearer ` - Price per tool call: $0.0001 (100 micro-USD) - Registry entry: - Every tool, machine-readable: ## Provider We proxy this provider under the terms below, re-checked on a schedule. If a re-check ever says no, the server and its tools leave the catalog and this page disappears with them. | Fact | Value | | --- | --- | | Terms of use | | | Terms verified on | 2026-09-19 | | API documentation | | | Upstream API key | none required | | Rate limit | 350 requests per minute | | Website | | | Compliance notes | 5 requests/second and 400/minute, dynamically throttled under load. | ## Attribution This provider requires the attribution below wherever you use results from its tools. Reproduce it verbatim: > Attribution to source recommended, not mandatory ## Tools (10) Every call below costs $0.0001 (100 micro-USD). Listing them costs nothing. | Tool | Description | Price per call | Documentation | | --- | --- | --- | --- | | `pubchem__pubchem_get_bioactivity` | Get a compound's bioactivity profile: which assays tested it, activity outcomes (Active/Inactive/Inconclusive), target identifiers (NCBI Gene ID, UniProt/GenBank accession), and quantitative values... | $0.0001 | [pubchem__pubchem_get_bioactivity](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_bioactivity) | | `pubchem__pubchem_get_compound_3d_structure` | Get a compound's default 3D conformer — atomic coordinates and bonds — for one CID. format="json" (default) returns atoms and bonds parsed into structured fields; format="sdf" returns the raw V2000... | $0.0001 | [pubchem__pubchem_get_compound_3d_structure](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_3d_structure) | | `pubchem__pubchem_get_compound_details` | Get detailed compound information by CID. Returns physicochemical properties (molecular weight, SMILES, InChIKey, XLogP, TPSA, etc.), optionally with a textual description (pharmacology, mechanism,... | $0.0001 | [pubchem__pubchem_get_compound_details](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_details) | | `pubchem__pubchem_get_compound_image` | Fetch a 2D structure diagram (PNG image) for a compound by CID. | $0.0001 | [pubchem__pubchem_get_compound_image](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_image) | | `pubchem__pubchem_get_compound_interactions` | Get a compound's interaction data: drug-drug interactions (DrugBank), drug-food interactions, and chemical-target interactions (binding/activity from BindingDB, ChEMBL, and others). Each entry carr... | $0.0001 | [pubchem__pubchem_get_compound_interactions](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_interactions) | | `pubchem__pubchem_get_compound_safety` | Get GHS (Globally Harmonized System) hazard classification and safety data for one or more compounds by CID. Returns signal word, pictograms, hazard statements (H-codes), and precautionary statemen... | $0.0001 | [pubchem__pubchem_get_compound_safety](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_safety) | | `pubchem__pubchem_get_compound_xrefs` | Get external database cross-references for a compound: PubMed citations, patent IDs, gene/protein associations, registry numbers, and taxonomy IDs. Results are paged per type — capped at maxPerType... | $0.0001 | [pubchem__pubchem_get_compound_xrefs](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_compound_xrefs) | | `pubchem__pubchem_get_summary` | Get descriptive summaries for PubChem entities by ID. Supports assays (AID), genes (Gene ID), proteins (UniProt accession), and taxonomy (Tax ID). Up to 10 per call. | $0.0001 | [pubchem__pubchem_get_summary](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_get_summary) | | `pubchem__pubchem_search_assays` | Find PubChem bioassays associated with a biological target. Search by gene symbol (e.g. "EGFR"), protein name, NCBI Gene ID, or UniProt accession. Returns a page of assay IDs (AIDs) — page past max... | $0.0001 | [pubchem__pubchem_search_assays](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_search_assays) | | `pubchem__pubchem_search_compounds` | Search PubChem for chemical compounds by identifier (name, SMILES, or InChIKey, batched up to 25), molecular formula in Hill notation, substructure or superstructure containment, or 2D Tanimoto sim... | $0.0001 | [pubchem__pubchem_search_compounds](https://gateway.mcpharbor.dev/docs/tools/pubchem__pubchem_search_compounds) | ## Price - $0.0001 (100 micro-USD) per tool call. - Billed on: each tools/call that reaches the upstream and returns a result. - Free: server/discover, tools/list, registry endpoints, docs files. - Payment: prepaid credits, drawn down per call. A call your balance cannot cover is refused with HTTP 402 before any upstream is contacted. - A charged call that then fails upstream is refunded automatically. - Retries are ordinary calls. There is no client idempotency key, so repeating a request that was already charged buys a second call - see [agent.txt](https://gateway.mcpharbor.dev/agent.txt), section 7.